Summer/Fall 2026

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Objectives

  1. Build a system that uses Frontier AI Labs for neoantigen prediction.
  2. Provide highly qualified neoantigen predictions for our candidate patient cases.
  3. Make models available as open source for others to use.

Neoantigen Analysis

  1. Individual neoantigen sets: prediction set (n~20) from each group.
  2. Gross neoantigen prediction lists.
  3. As a group, we will make a master composite list (n~20).

Immunogenicity Testing

We are evaluating to following options to test the 20 selected peptides.

  1. Peptide-MHC Binding Assays: measure ability of peptides to bind MHC class I molecules on cell surface or quantify binding affinity between peptide and soluble MHC proteins (Sette et al 2005) ProImmune offers this as a service
  2. Interferon (IFN)-γ ELISpot assay: measure T cell cytokine secretion (Charneau et al, Braun, )
  3. IFNg Intracellular Staining Assays (Flow Cytometry)
  4. Neoantigen T cell expansion: longer and more laborious, 7-10 days. (Sahin et al, 2017)

Expectations

  1. Each participating group submits a gross and ranked list of neoantigens for our patient datasets.
  2. Submissions remain confidential.
  3. Consortium participants will be included in publication in the **Research to the People Journal.**

*By requesting to join, you will be added to our mailing list.